BiopestPeptidV1, Main, Exploration, bibRecord, 000742

Preventive effects of bovine colostrum supplementation in TNBS-induced colitis in mice.

Identifieur interne : 000742 ( Main/Exploration ); précédent : 000741; suivant : 000743

Preventive effects of bovine colostrum supplementation in TNBS-induced colitis in mice.

Auteurs : Iulia Elena Filipescu [Italie] ; Leonardo Leonardi [Italie] ; Laura Menchetti [Italie] ; Gabriella Guelfi [Italie] ; Giovanna Traina [Italie] ; Patrizia Casagrande-Proietti [Italie] ; Federica Piro [Italie] ; Alda Quattrone [Italie] ; Olimpia Barbato [Italie] ; Gabriele Brecchia [Italie]

Source :

PloS one [ 1932-6203 ] ; 2018.

RBID : pubmed:30138385

Descripteurs français

KwdFr :
- Acide 2,4,6-trinitro-benzènesulfonique (MeSH), Agents protecteurs (usage thérapeutique), Animaux (MeSH), Bovins (MeSH), Charge bactérienne (MeSH), Colite (induit chimiquement), Colite (prévention et contrôle), Colostrum (MeSH), Cytokines (métabolisme), Microbiome gastro-intestinal (MeSH), Mâle (MeSH), Récepteur de type Toll-4 (métabolisme), Souris (MeSH).
MESH :
- induit chimiquement : Colite.
- métabolisme : Cytokines, Récepteur de type Toll-4.
- prévention et contrôle : Colite.
- usage thérapeutique : Agents protecteurs.
- Acide 2,4,6-trinitro-benzènesulfonique, Animaux, Bovins, Charge bactérienne, Colostrum, Microbiome gastro-intestinal, Mâle, Souris.

English descriptors

KwdEn :
- Animals (MeSH), Bacterial Load (MeSH), Cattle (MeSH), Colitis (chemically induced), Colitis (prevention & control), Colostrum (MeSH), Cytokines (metabolism), Gastrointestinal Microbiome (MeSH), Male (MeSH), Mice (MeSH), Protective Agents (therapeutic use), Toll-Like Receptor 4 (metabolism), Trinitrobenzenesulfonic Acid (MeSH).
MESH :
- chemical , metabolism : Cytokines, Toll-Like Receptor 4.
- chemically induced : Colitis.
- prevention & control : Colitis.
- chemical , therapeutic use : Protective Agents.
- Animals, Bacterial Load, Cattle, Colostrum, Gastrointestinal Microbiome, Male, Mice, Trinitrobenzenesulfonic Acid.

Abstract

Inflammatory bowel disease (IBD) is a chronic inflammatory disorder for which the current medical therapy is not completely effective. Bovine colostrum (BC) is a biological fluid rich in bioactive molecules that may have beneficial effects on several gastrointestinal disorders. The objectives of this study were to assess the preventive effects of BC supplementation in a mouse model of 2,4,6 trinitrobenzene sulfonic acid (TNBS)-induced colitis using a multidisciplinary approach. Specifically, the following parameters were evaluated: (i) disease activity index (DAI), (ii) histological score, (iii) expression levels of TLR4, anti- and pro-inflammatory cytokines, and (iv) count of some bacterial species of the intestinal microbiota. Mice received a daily suspension of BC (BC group, n = 12) or saline solution (control, CN group, n = 12) for 21 days before the intrarectal inoculation with 1% of TNBS solution. BC was well tolerated and did not induce any histological damage or clinical symptoms. After TNBS treatment, BC group showed a reduction of body weight (BW) loss (P<0.01) and histological score (P<0.05) compared to CN. Moreover, the expression levels of TLR4 (P<0.05), IL-1β (P<0.001), IL-8 (P<0.001), and IL-10 (P<0.001) were lower in mice administered with BC, while the concentrations of TNF-α did not show any differences between groups. Finally, the supplementation with BC resulted in a differential response to TNBS treatment in the bacterial count. In CN group, E. coli and Enterococci increased (P<0.001), while Anaerobes (P<0.01), Lactobacilli, and Bifidobacteria (P<0.001) reduced. Conversely, no significant changes in bacterial load were found after the inoculation of TNBS in BC pre-treated mice. This study confirms that TNBS-induced colitis model in mice is useful for studying the mechanisms involved in IBD pathogenesis and shows that pre-treatment with BC reduces the intestinal damages and clinical signs of the colitis. Molecular mechanisms and intestinal microflora could be involved in the protective effect of colostrum.

DOI: 10.1371/journal.pone.0202929
PubMed: 30138385
PubMed Central: PMC6107273

Affiliations:

Italie

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Le document en format XML

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<term>Bacterial Load (MeSH)</term>
<term>Cattle (MeSH)</term>
<term>Colitis (chemically induced)</term>
<term>Colitis (prevention & control)</term>
<term>Colostrum (MeSH)</term>
<term>Cytokines (metabolism)</term>
<term>Gastrointestinal Microbiome (MeSH)</term>
<term>Male (MeSH)</term>
<term>Mice (MeSH)</term>
<term>Protective Agents (therapeutic use)</term>
<term>Toll-Like Receptor 4 (metabolism)</term>
<term>Trinitrobenzenesulfonic Acid (MeSH)</term>
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<term>Agents protecteurs (usage thérapeutique)</term>
<term>Animaux (MeSH)</term>
<term>Bovins (MeSH)</term>
<term>Charge bactérienne (MeSH)</term>
<term>Colite (induit chimiquement)</term>
<term>Colite (prévention et contrôle)</term>
<term>Colostrum (MeSH)</term>
<term>Cytokines (métabolisme)</term>
<term>Microbiome gastro-intestinal (MeSH)</term>
<term>Mâle (MeSH)</term>
<term>Récepteur de type Toll-4 (métabolisme)</term>
<term>Souris (MeSH)</term>
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<keywords scheme="MESH" qualifier="prévention et contrôle" xml:lang="fr"><term>Colite</term>
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<keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Protective Agents</term>
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<term>Animaux</term>
<term>Bovins</term>
<term>Charge bactérienne</term>
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<front><div type="abstract" xml:lang="en">Inflammatory bowel disease (IBD) is a chronic inflammatory disorder for which the current medical therapy is not completely effective. Bovine colostrum (BC) is a biological fluid rich in bioactive molecules that may have beneficial effects on several gastrointestinal disorders. The objectives of this study were to assess the preventive effects of BC supplementation in a mouse model of 2,4,6 trinitrobenzene sulfonic acid (TNBS)-induced colitis using a multidisciplinary approach. Specifically, the following parameters were evaluated: (i) disease activity index (DAI), (ii) histological score, (iii) expression levels of TLR4, anti- and pro-inflammatory cytokines, and (iv) count of some bacterial species of the intestinal microbiota. Mice received a daily suspension of BC (BC group, n = 12) or saline solution (control, CN group, n = 12) for 21 days before the intrarectal inoculation with 1% of TNBS solution. BC was well tolerated and did not induce any histological damage or clinical symptoms. After TNBS treatment, BC group showed a reduction of body weight (BW) loss (P<0.01) and histological score (P<0.05) compared to CN. Moreover, the expression levels of TLR4 (P<0.05), IL-1β (P<0.001), IL-8 (P<0.001), and IL-10 (P<0.001) were lower in mice administered with BC, while the concentrations of TNF-α did not show any differences between groups. Finally, the supplementation with BC resulted in a differential response to TNBS treatment in the bacterial count. In CN group, E. coli and Enterococci increased (P<0.001), while Anaerobes (P<0.01), Lactobacilli, and Bifidobacteria (P<0.001) reduced. Conversely, no significant changes in bacterial load were found after the inoculation of TNBS in BC pre-treated mice. This study confirms that TNBS-induced colitis model in mice is useful for studying the mechanisms involved in IBD pathogenesis and shows that pre-treatment with BC reduces the intestinal damages and clinical signs of the colitis. Molecular mechanisms and intestinal microflora could be involved in the protective effect of colostrum.</div>
</front>
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<DateCompleted><Year>2019</Year>
<Month>02</Month>
<Day>08</Day>
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<Month>02</Month>
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<Issue>8</Issue>
<PubDate><Year>2018</Year>
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<Title>PloS one</Title>
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<ArticleTitle>Preventive effects of bovine colostrum supplementation in TNBS-induced colitis in mice.</ArticleTitle>
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<Abstract><AbstractText>Inflammatory bowel disease (IBD) is a chronic inflammatory disorder for which the current medical therapy is not completely effective. Bovine colostrum (BC) is a biological fluid rich in bioactive molecules that may have beneficial effects on several gastrointestinal disorders. The objectives of this study were to assess the preventive effects of BC supplementation in a mouse model of 2,4,6 trinitrobenzene sulfonic acid (TNBS)-induced colitis using a multidisciplinary approach. Specifically, the following parameters were evaluated: (i) disease activity index (DAI), (ii) histological score, (iii) expression levels of TLR4, anti- and pro-inflammatory cytokines, and (iv) count of some bacterial species of the intestinal microbiota. Mice received a daily suspension of BC (BC group, n = 12) or saline solution (control, CN group, n = 12) for 21 days before the intrarectal inoculation with 1% of TNBS solution. BC was well tolerated and did not induce any histological damage or clinical symptoms. After TNBS treatment, BC group showed a reduction of body weight (BW) loss (P<0.01) and histological score (P<0.05) compared to CN. Moreover, the expression levels of TLR4 (P<0.05), IL-1β (P<0.001), IL-8 (P<0.001), and IL-10 (P<0.001) were lower in mice administered with BC, while the concentrations of TNF-α did not show any differences between groups. Finally, the supplementation with BC resulted in a differential response to TNBS treatment in the bacterial count. In CN group, E. coli and Enterococci increased (P<0.001), while Anaerobes (P<0.01), Lactobacilli, and Bifidobacteria (P<0.001) reduced. Conversely, no significant changes in bacterial load were found after the inoculation of TNBS in BC pre-treated mice. This study confirms that TNBS-induced colitis model in mice is useful for studying the mechanisms involved in IBD pathogenesis and shows that pre-treatment with BC reduces the intestinal damages and clinical signs of the colitis. Molecular mechanisms and intestinal microflora could be involved in the protective effect of colostrum.</AbstractText>
</Abstract>
<AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Filipescu</LastName>
<ForeName>Iulia Elena</ForeName>
<Initials>IE</Initials>
<AffiliationInfo><Affiliation>Department of Veterinary Medicine, University of Perugia, Perugia, Italy.</Affiliation>
</AffiliationInfo>
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<Author ValidYN="Y"><LastName>Leonardi</LastName>
<ForeName>Leonardo</ForeName>
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</AffiliationInfo>
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<Author ValidYN="Y"><LastName>Menchetti</LastName>
<ForeName>Laura</ForeName>
<Initials>L</Initials>
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<AffiliationInfo><Affiliation>Department of Veterinary Medicine, University of Perugia, Perugia, Italy.</Affiliation>
</AffiliationInfo>
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<Author ValidYN="Y"><LastName>Guelfi</LastName>
<ForeName>Gabriella</ForeName>
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</AffiliationInfo>
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<ForeName>Giovanna</ForeName>
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</AffiliationInfo>
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<Author ValidYN="Y"><LastName>Casagrande-Proietti</LastName>
<ForeName>Patrizia</ForeName>
<Initials>P</Initials>
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</AffiliationInfo>
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Preventive effects of bovine colostrum supplementation in TNBS-induced colitis in mice.

Preventive effects of bovine colostrum supplementation in TNBS-induced colitis in mice.

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